Author

Varun Ramaswamy

Institute of Structural and Molecular Biology, Birkbeck, University of London, UK;ORCID 0000-0003-4918-8844Unclaimed ORCID profile · follow to get notified of new preprints

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Biophysics· 1

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Approach:experimental assay· 1

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Ankit Rai· 1 shared Anna AkhmanovaiD· 1 shared Carolyn MooresiD· 1 shared Darsh D Sharma· 1 shared Szymon W MankaiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Ankit Rai

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BiophysicsbioRxivPreprintNov 4, 2026

STRUCTURAL PLASTICITY ALLOWS DOUBLECORTIN AND DRUG-STABILIZED MICROTUBULES TO ACCOMMODATE EACH OTHER

Varun Ramaswamy, Szymon W Manka, Darsh D Sharma…·Carolyn Moores

This study shows that taxane-stabilized microtubules can adopt 15-protofilament structures, which DCX can bind through conformational remodeling, contrasting with the rigid GMPCPP-stabilized lattice.

DOI 10.64898/2026.11.03.763982

experimental assay

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