Anna S. Akhmanova

This study shows that taxane-stabilized microtubules can adopt 15-protofilament structures, which DCX can bind through conformational remodeling, contrasting with the rigid GMPCPP-stabilized lattice.

The paper identifies a conserved mechanism for polar protein targeting in plants using proteomics and shows PAT19 mediates SOSEKI1 membrane localization in Arabidopsis and other species.

The paper investigates pathways controlling microtubule density in interphase cells by disrupting CAMSAP and γ-TuRC pathways, revealing redundant activation mechanisms.

This study uses cryo-EM and cryo-ET to reveal how the WD40 domain of KIF21B interacts with microtubules, identifying two binding states and suggesting its role in microtubule regulation.

The paper reports the structure of the mammalian ciliary transition zone microtubule doublet using cryo-electron tomography, revealing unique proteins and their roles in microtubule stabilization and transport regulation.

The paper uses expansion microscopy to map the 3D microtubule organization in human airway multiciliated cells, revealing the role of NEDD1 in basal foot-dependent microtubule organization.

This study investigates how Katanin, CAMSAPs, WDR47, and kinesin-13 regulate microtubule abundance and minus-end dynamics through in vitro reconstitution.

This study shows taxanes induce conformational changes in microtubules, releasing GEF-H1 and activating RhoA signaling, leading to actin remodeling.

This study uses expansion microscopy to show SARS-CoV-2 exits cells via Rab27-dependent amphisome fusion, identifying a potential therapeutic target.

The paper describes the immortalization of human nasal and bronchial airway epithelial cells using hTERT overexpression, enabling long-term genome editing studies.

The paper introduces CHalo reagents that conditionally ligate to HaloTag proteins, enabling light- or enzyme-triggered labeling, protein recruitment control, and enzyme activity recording.

The paper shows how LC8 converts the disordered KANK1 linker into a rod-like structure through cooperative multivalency, resolving a cellular architecture paradox.

This study develops optogenetic and chemical genetic tools to rapidly manipulate vimentin intermediate filaments and examines their immediate effects on cellular structures.

This study identifies SSNA1 as a centriolar protein in the distal lumen that promotes ciliogenesis without microtubule association, challenging previous views of its function.

The paper investigates the interactions of ciliary tip proteins and their role in microtubule dynamics, finding that they form structures that slow and processively elongate microtubules.

The paper shows that microtubule lattice spacing affects kinesin-1 binding, with expanded lattices preferentially bound by kinesin-1.

The paper identifies BBLN-1 as a regulator of lumen morphology in C. elegans intestine and identifies its mammalian ortholog bublin, which can compensate for its loss.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

The paper shows that dynein plus-end tracking in C. elegans depends on EBP-2, but spindle positioning remains normal without EBP proteins.