Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation
Silke Fuchs, William T. Garrood, Anna Beber, Andrew Hammond, Roberto Galizi, Matt Gribble, Giulia Morselli, Tin‐Yu J. Hui, Katie D. Willis, Nace Kranjc, Austin Burt, Tony Nolan, Andrea Crisanti
The paper evaluates resistance to a CRISPR-based gene drive by simulating high selection pressure in Anopheles gambiae and identifies a resistant mutation at an ultra-conserved site.
PLoS Genetics · Oct 5, 2021Peer-reviewedGenetics