Author

Silke Fuchs

Imperial College LondonORCID 0000-0001-8921-7422Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Organism:multiple species· 1

Frequent Co-Authors

Andrea CrisantiiD· 2 shared Austin BurtiD· 2 shared Roberto GaliziiD· 2 shared Tony NolaniD· 2 shared Andrew HammondiD· 1 shared Anna Beber· 1 shared Annie J. ForsteriD· 1 shared Douglas B. RuschiD· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Andrea CrisantiORCID

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3 papers

Recent·Most cited

GeneticsFrontiers in Bioengineering and BiotechnologyPeer-reviewedDec 3, 2021

The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes

Yehonatan Alcalay, Silke Fuchs, Roberto Galizi…·Philippos Aris Papathanos

The paper analyzes the potential for an autosomal X-shredder to become a Y-linked drive element in malaria mosquitoes and concludes it is unlikely due to suppression mechanisms.

25 citations

mousestatistical model

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedOct 5, 2021

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

Silke Fuchs, William T. Garrood, Anna Beber…·Andrea Crisanti

The paper evaluates resistance to a CRISPR-based gene drive by simulating high selection pressure in Anopheles gambiae and identifies a resistant mutation at an ultra-conserved site.

41 citations

CRISPR screenexperimental assay

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GenomicsG3 Genes Genomes GeneticsPeer-reviewedMar 17, 2021

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control.

Samantha M. O’Loughlin, Annie J. Forster, Silke Fuchs…·Austin Burt

The paper identifies ultra-conserved sequences in Anopheles mosquito genomes and suggests their potential use as targets for gene drive-based malaria control.

7 citations

multiple specieswhole-genome sequencing

𝕏 PostBluesky