Andrew Hammond

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

The paper develops a neurogenetic toolkit to study olfaction in Anopheles gambiae by targeting specific olfactory sensory neuron subsets and analyzing their responses to human-related odorants.

The paper evaluates resistance to a CRISPR-based gene drive by simulating high selection pressure in Anopheles gambiae and identifies a resistant mutation at an ultra-conserved site.

This study improves gene drive efficacy by reducing resistance and fitness costs through regulatory sequence modifications, leading to better population suppression and delayed resistance.

The paper demonstrates that Y chromosomes from two malaria vector species in the Anopheles gambiae complex function interchangeably, suggesting no hybrid incompatibility loci on the Y and enabling potential cross-species sex-distorting Y drive interventions.