Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation
Huanhuan Liu, Anupama Binoy, Siqi Ren, T. C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Abhijit Sukul, Joanna Bons, Jacob Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu
This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.
Arthritis & Rheumatology · Apr 3, 2025Peer-reviewedCell Biology