Huanhuan Liu

This study shows hypobaric hypoxia suppresses tumor progression by reprogramming the citrate cycle and inhibiting the HIF-1 pathway, enhancing antitumor immune response and improving therapy outcomes.

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

This study de novo assembles high-quality genomes of 38 Arabidopsis thaliana ecotypes using long-read sequencing, identifies new genes and structural variations linked to local adaptation, and highlights the role of SVs in environmental adaptation.

This study shows that exosomes from premature infant urine reduce cisplatin-induced acute kidney injury in mice by delivering miR-30a-5p, which targets MAPK8 to prevent apoptosis.

This paper develops regBase, a database of whole genome base-wise aggregations of regulatory variant predictions, and three composite models to score functional, pathogenic, and cancer driver variants, showing superior performance in fine-mapping causal variants.