Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical Microenvironment
Marta Sánchez-Carbonell, Sonia Bolshakova, Juan E Ávila-Pagán, Yaseer A. Sabir, Clay Griffin-Derr, Dominik Stich, Sofia V Cieslewicz, Sheyla Carmen-Sifuentes, Rhushikesh A. Phadke, Alison Brack, Anna Hasche-Kluender, Paige Caley, Caroline Dias, Alberto Cruz‐Martín
This study shows that sparse neuronal C4 elevation induces broad transcriptomic and lipid-droplet remodeling in the cortical microenvironment, suggesting non-cell-autonomous effects on neighboring cells.
bioRxiv · May 29, 2025 · PreprintNeuroscience