Sonia Bolshakova

The paper uses village editing to study how genetic backgrounds affect the impact of schizophrenia-associated mutations in human neurons.

This study shows that sparse neuronal C4 elevation induces broad transcriptomic and lipid-droplet remodeling in the cortical microenvironment, suggesting non-cell-autonomous effects on neighboring cells.

The paper identifies genetic variants that influence neuronal responses to interferons by analyzing gene expression and STAT1 binding in iPSC-derived neurons.

This study shows that overexpressing the schizophrenia risk gene C4 in PV cells causes sex-dependent behavioral and circuit dysfunction in mice.