Author

Alison Brack

Boston UniversityORCID 0000-0002-4401-6501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Assay:imaging· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Alberto Cruz‐MartíniD· 6 shared Rhushikesh A. PhadkeiD· 6 shared Luke A. FournieriD· 5 shared Maria Salgado· 3 shared Berta Escude Velasco· 2 shared Charlotte Yeung· 2 shared Connor JohnsoniD· 2 shared Mingqi ShaiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersNeuroscience

Alberto Cruz‐MartínORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Environmental risk reshapes high-confidence schizophrenia risk genes during a developmental window of vulnerability

Alison Brack, Rhushikesh A. Phadke, Luke A. Fournier, Matthew J. Boberg, Maria Salgado, Alberto Cruz‐Martín

The paper investigates how early-life stress alters the expression of schizophrenia risk genes in mice during development, identifying region- and cell-type-specific effects.

bioRxiv · Oct 28, 2026 · PreprintNeuroscience

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical Microenvironment

Marta Sánchez-Carbonell, Sonia Bolshakova, Juan E Ávila-Pagán, Yaseer A. Sabir, Clay Griffin-Derr, Dominik Stich, Sofia V Cieslewicz, Sheyla Carmen-Sifuentes, Rhushikesh A. Phadke, Alison Brack, Anna Hasche-Kluender, Paige Caley, Caroline Dias, Alberto Cruz‐Martín

This study shows that sparse neuronal C4 elevation induces broad transcriptomic and lipid-droplet remodeling in the cortical microenvironment, suggesting non-cell-autonomous effects on neighboring cells.

bioRxiv · May 29, 2025 · PreprintNeuroscience

REVEALS: An Open Source Multi Camera GUI For Rodent Behavior Acquisition

Rhushikesh A. Phadke, Austin M. Wetzel, Luke A. Fournier, Alison Brack, Mingqi Sha, Nicole M. Padró-Luna, W. Ryan Williamson, Jeffrey Demas, Alberto Cruz‐Martín

REVEALS is an open-source GUI for rodent behavior data acquisition using multiple cameras, validated with DeepLabCut for pose estimation in behavioral assays.

Cerebral Cortex · Oct 1, 2024Peer-reviewedNeuroscience

Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.

Luke A. Fournier, Rhushikesh A. Phadke, Maria Salgado, Alison Brack, Jian Carlo Nocon, Sonia Bolshakova, Jaylyn R. Grant, Nicole M. Padró-Luna, Kamal Sen, Alberto Cruz‐Martín

This study shows that overexpressing the schizophrenia risk gene C4 in PV cells causes sex-dependent behavioral and circuit dysfunction in mice.

iScience · Aug 30, 2024Peer-reviewedNeuroscience

C4 induces pathological synaptic loss by impairing AMPAR trafficking.

Rhushikesh A. Phadke, Ezra Kruzich, Luke A. Fournier, Alison Brack, Mingqi Sha, Ines Picard, Connor Johnson, Dimitri Stroumbakis, Maria Salgado, Charlotte Yeung, Berta Escude Velasco, Yen Yu Liu, Alberto Cruz‐Martín

This study shows that C4 overexpression causes synaptic loss by impairing GluR1 trafficking via SNX27, independent of the complement pathway.

bioRxiv · Sep 9, 2023 · PreprintNeuroscience

Distinct VIP interneurons in the cingulate cortex encode anxiogenic and social stimuli

Connor Johnson, Lisa N. Kretsge, William Yen, Balaji Sriram, Alexandra O’Connor, Ruichen Sky Liu, Jessica Jimenez, Rhushikesh A. Phadke, Kelly K. Wingfield, Charlotte Yeung, Tushare Jinadasa, Thanh P. H. Nguyen, Eun Seon Cho, Erelle Fuchs, Eli D. Spevack, , Alberto Cruz‐Martín

The paper identifies distinct VIP interneuron subpopulations in the ACC that selectively encode anxiogenic, anxiolytic, social, or non-social stimuli in mice.

Molecular Psychiatry · Mar 4, 2022Peer-reviewedNeuroscience

Chromatin potential identified by shared single cell profiling of RNA and chromatin

Sai Ma, Bing Zhang, Lindsay M. LaFave, Andrew Earl, Zachary Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K. Kartha, Tristan Tay, Travis E. Law, Caleb A. Lareau, Ya‐Chieh Hsu, Aviv Regev, Jason Daniel Buenrostro

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.

Cell · Oct 23, 2020Peer-reviewedGenomics