Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance
Frederik Eikens, Lena Wischhof, Anna Henrich, Lena Erlebach, Annett Halle, Hannah Scheiblich
This study shows that inflammatory activation impairs microglial degradation of protein aggregates by creating a lysosomal bottleneck, without affecting their uptake.
bioRxiv · Nov 3, 2026 · PreprintCell Biology