Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
Jose Cabezas-Caballero, Anna Huhn, Mikhail A. Kutuzov, Violaine Andre, Alina S. Shomuradova, Bas W. A. Peeters, Geraldine M. Gillespie, P. Anton van der Merwe, Omer Dushek
This study shows that switching CD8 with CD4 co-receptor in cytotoxic T cells reduces off-target cross-reactivity without altering the TCR, enhancing T cell therapy safety.
Nature Biomedical Engineering · Jan 2, 2026Peer-reviewedImmunology