Jose Cabezas-Caballero

This study shows that switching CD8 with CD4 co-receptor in cytotoxic T cells reduces off-target cross-reactivity without altering the TCR, enhancing T cell therapy safety.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

This study assesses gene essentiality across diverse E. coli strains and growth conditions, revealing that essentiality varies independently of phylogeny and is influenced by mobile genetic elements.