Omer Dushek

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This paper introduces NanoBondy, a covalent cell-surface modification technology for immune cells using NeissLock chemistry, demonstrating robust and specific ligation to CD45.

This study shows that switching CD8 with CD4 co-receptor in cytotoxic T cells reduces off-target cross-reactivity without altering the TCR, enhancing T cell therapy safety.

This study develops a peptide-exchange system to efficiently study KIR binding to HLA-I molecules with peptide specificity.

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.

This paper measures 3D affinities of the OT-I TCR to 19 pMHC complexes and finds they strongly correlate with 2D membrane affinities, revealing imperfect antigen discrimination.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

The paper investigates how ACE2 missense variants affect SARS-CoV-2 Spike binding, identifying variants that enhance or inhibit binding and their potential impact on infection risk.