Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities
R. Blake Richardson, Caroline Kikawa, Amit Garg, Eva Bednarski, Madihah S. Salim, David J. Bacsik, Ethan C. Veit, Anna I. Hermacinski, Rachael E. Hamilton, Adolfo García‐Sastre, Jesse D. Bloom, Jean K. Lim, Matthew J. Evans
This study identifies evolutionary constraints linking Zika virus NS5 replication and interferon antagonism by analyzing fitness landscapes and attenuation in mice.
Nature Communications · Oct 28, 2026Peer-reviewedMicrobiology