A diffusion-like process enables expansion of advantaged gene mutations in human colonic epithelium
Cora Olpe, Doran Khamis, Maria Chukanova, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Nefeli Skoufou-Papoutsaki, Anna M Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier ten Hoopen, Rachel Stanley, Edward Morrissey, Douglas J Winton
The paper quantifies clonal expansion of KDM6A-negative mutations in human colonic epithelium and proposes crypt diffusion as a mechanism for accommodating clonal growth.
bioRxiv · Jul 10, 2020 · PreprintCancer Biology