Author

Rogier ten Hoopen

University of CambridgeORCID 0000-0003-0655-9182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Roxanne Brunton-Sim· 2 shared Anna M Nicholson· 1 shared Bernard C. H. Lee· 1 shared Cecilia Lindskog· 1 shared Cerys Tatton· 1 shared Cora Olpe· 1 shared Doran Khamis· 1 shared Douglas J Winton· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenomics

Roxanne Brunton-Sim

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2 papers

Recent·Most cited

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Ólafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs Arnoud Sanders, Stefanie V. Lensing, , Michael R. Stratton

This study shows that inherited MUTYH mutations increase somatic mutation rates and specific mutational signatures in normal human cells, contributing to cancer risk without causing premature aging.

Nature Communications · Jul 8, 2022Peer-reviewedGenomics

A diffusion-like process enables expansion of advantaged gene mutations in human colonic epithelium

Cora Olpe, Doran Khamis, Maria Chukanova, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Nefeli Skoufou-Papoutsaki, Anna M Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier ten Hoopen, Rachel Stanley, Edward Morrissey, Douglas J Winton

The paper quantifies clonal expansion of KDM6A-negative mutations in human colonic epithelium and proposes crypt diffusion as a mechanism for accommodating clonal growth.

bioRxiv · Jul 10, 2020 · PreprintCancer Biology