Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming
Adam J. Dourson, Adewale Oluwaseun Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme, Megan C. Hofmann, Heather M. Evans, Omer A. Donmez, Carmy R. Forney, Matthew T. Weirauch, Leah Claire Kottyan, Daniel Lucas, George S. Deepe, Michael P. Jankowski
This study shows that macrophage epigenetic changes from early life injury influence pain responses later in life, with a focus on sex-specific effects.
bioRxiv · Feb 13, 2023 · PreprintNeuroscience