Adam J. Dourson

This study examines the relationship between sex hormone levels and endometriosis-related pain in women, finding weak associations between specific receptor transcript levels and pain intensity.

The paper identifies hyperexcitable Ret/GFRα1+ nociceptors innervating endometriosis lesions that correlate with GDNF levels and clinical pain.

This study identifies Pdyn-lineage neurons as sensory enteric neurons in the mouse colon that regulate motility and visceral interoception through optogenetic activation.

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

The paper investigates how endocrine signaling and neuroimmune communication regulate neonatal pain, finding that GH signaling via STAT1 influences inflammatory pain through a novel neuroimmune loop.

This study shows that macrophage epigenetic changes from early life injury influence pain responses later in life, with a focus on sex-specific effects.

The paper investigates how growth hormone signaling in the periphery modulates neonatal nociception, finding that GH receptor signaling inhibits hypersensitivity and that injury disrupts this by sequestering GH via macrophages.