Michael P. Jankowski

This study identifies a type 2 neuroimmune circuit involving IL-4 receptor-dependent DRG responses that modify esophageal inflammation in eosinophilic esophagitis.

The paper investigates how endocrine signaling and neuroimmune communication regulate neonatal pain, finding that GH signaling via STAT1 influences inflammatory pain through a novel neuroimmune loop.

The paper shows that Schwann cell Nf1 loss causes mechanical pain via GDNF release, which affects adjacent neurons, suggesting cell-specific treatment strategies for NF1-related pain.

This study investigates the sex-specific role of AUF1 in modulating gene expression and hypersensitivity after repeated ischemia-reperfusion injury in mice.

This study shows that macrophage epigenetic changes from early life injury influence pain responses later in life, with a focus on sex-specific effects.

The paper investigates how growth hormone signaling in the periphery modulates neonatal nociception, finding that GH receptor signaling inhibits hypersensitivity and that injury disrupts this by sequestering GH via macrophages.

This study shows that GDNF signaling in muscle afferents enhances both nociception and cardiovascular reflexes following ischemic injury.

The paper uses single cell qPCR and functional assays to correlate gene expression with functional properties in identified sensory neurons, finding transcriptional heterogeneity within functional subgroups.