Author

Megan C. Hofmann

Cincinnati Children's Hospital Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Michael P. JankowskiiD· 4 shared Adam J. DoursoniD· 3 shared Adewale Oluwaseun FadakaiD· 2 shared Luis F. QuemeiD· 2 shared Namrata G.R. RautiD· 2 shared Aaditya Adlakha· 1 shared Aditi ParanjpeiD· 1 shared Anna M. Warshak· 1 shared

Activity by Year

2021-2024 · peak 2/yr

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10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Michael P. JankowskiORCID

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4 papers

Recent·Most cited

The intersection of endocrine signaling and neuroimmune communication regulates neonatal nociception

Adewale Oluwaseun Fadaka, Adam J. Dourson, Megan C. Hofmann, Prakriti Gupta, Namrata G.R. Raut, Michael P. Jankowski

The paper investigates how endocrine signaling and neuroimmune communication regulate neonatal pain, finding that GH signaling via STAT1 influences inflammatory pain through a novel neuroimmune loop.

bioRxiv · Jul 26, 2024 · PreprintNeuroscience

Schwann cells modulate nociception in neurofibromatosis 1

Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt, Irati Mitxelena, Aaditya Adlakha, Kourtney L. Sprague, Ashley R. Rupert, Lane Bokros, Megan C. Hofmann, Jennifer Patritti Cram, Tilat A. Rizvi, Luis F. Queme, Kwangmin Choi, Nancy Ratner, Michael P. Jankowski

The paper shows that Schwann cell Nf1 loss causes mechanical pain via GDNF release, which affects adjacent neurons, suggesting cell-specific treatment strategies for NF1-related pain.

JCI Insight · Jan 22, 2024Peer-reviewedNeuroscience

Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming

Adam J. Dourson, Adewale Oluwaseun Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme, Megan C. Hofmann, Heather M. Evans, Omer A. Donmez, Carmy R. Forney, Matthew T. Weirauch, Leah Claire Kottyan, Daniel Lucas, George S. Deepe, Michael P. Jankowski

This study shows that macrophage epigenetic changes from early life injury influence pain responses later in life, with a focus on sex-specific effects.

bioRxiv · Feb 13, 2023 · PreprintNeuroscience

Early life nociception is influenced by peripheral growth hormone signaling

Adam J. Dourson, Zachary K. Ford, Kathryn J. Green, Carolyn E. McCrossan, Megan C. Hofmann, Renita C. Hudgins, Michael P. Jankowski

The paper investigates how growth hormone signaling in the periphery modulates neonatal nociception, finding that GH receptor signaling inhibits hypersensitivity and that injury disrupts this by sequestering GH via macrophages.

Journal of Neuroscience · Apr 22, 2021Peer-reviewedNeuroscience