Reverse transcriptase inhibitors induce autophagy in a LINE-1 ORF1p-dependent manner
Michela Damizia, Mirko Baranzini, Ilaria Sciamanna, Ludovica Altieri, Paola Rovella, Omar G. Rosas Bringas, Samira Hozeifi, Leila J Saba, Apostolos Mourtzinos, Anna O'shea, Mohammad Salik Zeya Ansari, Federica Andreola, Roberto Cirilli, Gianluca Sbardella, Annalucia Serafino, , Corrado Spadafora
This study shows reverse transcriptase inhibitors induce autophagy in cancer cells through LINE-1 ORF1p-dependent mechanisms involving DNA damage and lamin B1 interactions.
Communications Biology · Sep 17, 2026Peer-reviewedCell Biology