Author

Samira Hozeifi

University Medical Center GroningenORCID 0000-0002-2851-2425Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Apostolos MourtzinosiD· 2 shared John LaCavaiD· 2 shared Omar G. Rosas BringasiD· 2 shared Alienke van PijkereniD· 1 shared Anna O'shea· 1 shared Annalucia SerafinoiD· 1 shared Brian T. ChaitiD· 1 shared Corrado SpadaforaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Apostolos MourtzinosORCID

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2 papers

Recent·Most cited

Reverse transcriptase inhibitors induce autophagy in a LINE-1 ORF1p-dependent manner

Michela Damizia, Mirko Baranzini, Ilaria Sciamanna, Ludovica Altieri, Paola Rovella, Omar G. Rosas Bringas, Samira Hozeifi, Leila J Saba, Apostolos Mourtzinos, Anna O'shea, Mohammad Salik Zeya Ansari, Federica Andreola, Roberto Cirilli, Gianluca Sbardella, Annalucia Serafino, , Corrado Spadafora

This study shows reverse transcriptase inhibitors induce autophagy in cancer cells through LINE-1 ORF1p-dependent mechanisms involving DNA damage and lamin B1 interactions.

Communications Biology · Sep 17, 2026Peer-reviewedCell Biology

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions

Mathias Ingemann Nielsen, Justina Clarinda Wolters, Omar G. Rosas Bringas, Hua Liang Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava

This paper develops targeted mass spectrometry assays to detect and quantify endogenous ORF1p and ORF2p proteins, demonstrating sensitive and robust quantitation of ORF2p for the first time.

Mobile DNA · Feb 6, 2025Peer-reviewedMolecular Biology