SLAMF6 enables efficient attachment, synapse formation, and killing of HIV-1-infected CD4+ T cells by virus-specific CD8+ T cells
Blandine Monel, Pedro A. Lamothe, James Meyo, Anna P. McLean, Raymond Quiñones‐Alvarado, Mélanie Laporte, Julie Boucau, Bruce D. Walker, Daniel G. Kavanagh, Wilfredo F. García-Beltrán, Yovana Pacheco
This study shows that SLAMF6 is essential for CD8+ T cells to form synapses and kill HIV-1-infected CD4+ T cells, as blocking SLAMF6 reduces conjugate formation and cytotoxicity.
bioRxiv · Jan 20, 2025 · PreprintImmunology