Dynamic association of IκBα to chromatin is regulated by acetylation and cleavage of histone H4
Laura Marruecos, Joan Bertran, Daniel Alvarez Villanueva, María Carmen Mulero, Yolanda Guillén, Luis G Palma, Martin Floor, Anna Vert, Sara Arce‐Gallego, Irene Pecharromán, Laura Batlle‐Morera, Jordi Villà-Freixa, Gourisankar Ghosh, Anna Bigas, Lluı́s Espinosa
The paper shows that phosphorylated IκB binds chromatin via acetylated H4 and that proteolytic cleavage of H4 inhibits this binding, affecting intestinal cell differentiation.
EMBO Reports · Jul 5, 2021Peer-reviewedMolecular Biology