Luis G Palma

The paper shows RNA m6A modifications coordinate with de novo DNA methylation to establish heritable epigenetic silencing in human cells.

CRISPRtune is a programmable tool that tunes transcriptional repression by fusing MeCP2 to dCas9, enabling intermediate gene expression control in human cells.

LEMONmethyl-seq profiles DNA methylation dynamics in mammalian cells, revealing CRISPR-induced changes and endogenous patterns, including non-canonical CpH methylation.

This study identifies the IFNγ pathway's role in accelerating iPSC reprogramming and X-chromosome reactivation through STAT3 signaling and TET-mediated demethylation.

The paper shows that phosphorylated IκB binds chromatin via acetylated H4 and that proteolytic cleavage of H4 inhibits this binding, affecting intestinal cell differentiation.