Lluı́s Espinosa

SMARCA4 MUTATIONS PROMOTE CHEMOTHERAPY RESISTANCE IN T-ACUTE LYMPHOBLASTIC LEUKEMIA THROUGH ALTERED CHROMATIN REMODELING AT AP1-ASSOCIATED REGULATORY REGIONS

This study shows SMARCA4 mutations in T-ALL lead to chemotherapy resistance by altering chromatin remodeling at AP-1 regulatory regions, reducing stress response genes.

Developmental programming of hematopoietic stem cell dormancy by evasion of Notch signaling

This study identifies a developmental program for hematopoietic stem cell (HSC) dormancy established during embryogenesis through evasion of Notch signaling, revealing a mechanism for long-term regenerative potential.

Diverse transcriptomic and mutational patterns but limited functional pathway alterations in patient-derived SS cells

The paper analyzes patient-derived SS cells to identify transcriptomic, mutational patterns, and functional pathway alterations, finding limited pathway changes but potential for MALT1 inhibition in therapy.

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson's disease by targeting receptor interleukin-6

The paper shows that tocilizumab, an IL-6 receptor inhibitor, prevents astrocyte-induced neurotoxicity in Parkinson's disease by blocking IL-6 signaling in neurons.

Radical fringe facilitates NOTCH1 and JAG1 cis interactions to sustain Hematopoietic stem cell fate

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

Dynamic association of IκBα to chromatin is regulated by acetylation and cleavage of histone H4

The paper shows that phosphorylated IκB binds chromatin via acetylated H4 and that proteolytic cleavage of H4 inhibits this binding, affecting intestinal cell differentiation.

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

This study identifies a role for C. elegans I{kappa}B homologs in chromatin regulation, showing they bind histones, Polycomb proteins, and alter chromatin marks, suggesting ancestral I{kappa}B functions in development.

Notch ligand Dll4 impairs cell recruitment into aortic clusters and limits hematopoietic stem cells

The paper shows that Dll4 inhibits cell recruitment into aortic clusters, reducing hematopoietic stem cell formation.