ASPP2/PP1 complexes maintain the integrity of pseudostratified epithelia undergoing remodelling during morphogenesis
Christophe Royer, Elizabeth Sandham, Elizabeth A. Slee, Jonathan Godwin, Nisha Veits, Holly Hathrell, Felix Zhou, Karolis Leonavicius, Jemma Garratt, Tanaya Narendra, Anna Vincent, Céline Jones, Tim J. Child, Kevin Coward, Chris Graham, , Shankar Srinivas
This study identifies the ASPP2/PP1 complex as critical for maintaining pseudostratified epithelial integrity during morphogenesis by preventing apical delamination and supporting F-actin organization.
bioRxiv · Nov 3, 2020 · PreprintDevelopmental Biology