Shankar Srinivas

The paper investigates the role of calcium signaling in anterior-posterior axis formation in the mouse embryo, finding that SERCA inhibition disrupts DVE migration and axial patterning.

The paper identifies enhancers regulating Chd7 expression in neural crest cells and validates their function in chick embryos, revealing tissue-specific regulation of a chromatin remodeller.

The paper characterizes the transcriptional dynamics of the mouse Anterior Visceral Enderm (AVE) during migration and identifies Ephrin- and Semaphorin-signalling as critical for its movement.

The paper uses single-cell phenomics to study DVE cell migration in mouse embryos, revealing mechanical heterogeneities and how surrounding cells facilitate collective migration.

This study identifies asymmetrically expressed genes in the mouse cardiac crescent during left-right symmetry breaking using single-cell RNA sequencing and validates their expression patterns.

CIARA identifies markers of rare cell types from single-cell RNA-seq data, outperforming existing methods and discovering new cell populations in mouse and human samples.

This paper presents a spatially resolved single-cell transcriptome atlas of human gastrulation, identifying novel cell types and revealing key differences from mouse gastrulation.

This paper uses spatial transcriptomics to study mouse organogenesis, revealing spatial gene expression patterns and cell fate decisions not captured by single-cell RNA sequencing.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

This study identifies the ASPP2/PP1 complex as critical for maintaining pseudostratified epithelial integrity during morphogenesis by preventing apical delamination and supporting F-actin organization.

The paper observes that non-apical mitosis in the posterior epiblast precedes gastrulation and is associated with cell delamination during epithelial-mesenchymal transition.

The paper introduces SilentMark, a lightweight image analysis tool for spatial protein analysis in mammalian tissues, capable of handling noisy and crowded images and providing geometry-based quantification.

The paper shows that blastomere position during early embryogenesis influences YAP localization through apicobasal polarity and PKC signaling, affecting cell fate decisions.