The paper characterizes the transcriptional dynamics of the mouse Anterior Visceral Enderm (AVE) during migration and identifies Ephrin- and Semaphorin-signalling as critical for its movement.

25 citations

mousescRNA-seq

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Developmental BiologybioRxivPreprintMar 31, 2023

Single-cell phenomics reveals behavioural and mechanical heterogeneities underpinning collective migration during mouse anterior patterning

Matthew J. Stower, Felix Zhou, Holly Hathrell…·Shankar Srinivas

The paper uses single-cell phenomics to study DVE cell migration in mouse embryos, revealing mechanical heterogeneities and how surrounding cells facilitate collective migration.

12 citations

mousespatial transcriptomics

𝕏 PostBluesky

Developmental BiologybioRxivPreprintNov 3, 2020

ASPP2/PP1 complexes maintain the integrity of pseudostratified epithelia undergoing remodelling during morphogenesis

Christophe Royer, Elizabeth Sandham, Elizabeth A. Slee…·Shankar Srinivas

This study identifies the ASPP2/PP1 complex as critical for maintaining pseudostratified epithelial integrity during morphogenesis by preventing apical delamination and supporting F-actin organization.

DOI 10.1101/2020.11.03.366906

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedDec 28, 2018

The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome

Michal Ryszard Gdula, Tatyana B. Nesterova, Greta Pintacuda…·Neil Brockdorff

This study shows that SmcHD1 prevents TAD formation on the inactive X chromosome by altering chromatin structure and epigenetic marks.

121 citationstop 2%

mouseChIP-seq

𝕏 PostBluesky