Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy.
Laura A. Ewell, Ario Dustin Ramezani, Gabrielle Suarez, Verónica C. Piatti, Vicky T. Lam, Tatyana G. Mills, Anelah K. McGinness, Raafat Kuk, Mika Ukai, Anna-Lena Schlenner, Christopher K. Luong, Stefan Leutgeb, Jill K. Leutgeb
This study shows that early in temporal lobe epilepsy, the dentate gyrus has impaired pattern separation despite stable spatial coding, linking network changes to memory deficits.
bioRxiv · Nov 12, 2025 · PreprintNeuroscience