Laura A. Ewell

The paper shows that reward-tethered place cells in the hippocampus adjust their activity when reward magnitude changes, enabling flexible coding and remapping while preserving spatial maps.

The paper investigates spatial coding deficits in hippocampal subfields of mice with temporal lobe epilepsy, finding specific impairments in place cell properties across subfields.

This study shows that early in temporal lobe epilepsy, the dentate gyrus has impaired pattern separation despite stable spatial coding, linking network changes to memory deficits.

The paper identifies a third type of dentate spike (DS3) that represents a continuous distribution of input strength from lateral and medial entorhinal cortex, challenging the traditional bimodal classification.

The paper investigates how interictal spikes affect spatial working memory in mice, finding that clustered spikes at reward locations improve performance while dispersed spikes impair it.

This study identifies region-specific spreading depolarization as a key factor in post-ictal behavioral abnormalities in epilepsy using mouse and human data.

This study shows that concussive brain injury impairs pattern separation in the dentate gyrus, affecting both cellular decorrelation of temporal inputs and behavioral discrimination of similar spatial locations.

The paper identifies a Na+ channel-dependent mechanism in hippocampal dendrites that contributes to spatial memory deficits in epilepsy and shows that targeting Nav1.3 channels can reverse these deficits.

The paper presents a low-cost platform for multi-animal chronic seizure monitoring with real-time synchronization of video and local field potential data, along with a user-friendly GUI for seizure detection and behavioral scoring.

The paper shows that dentate gyrus activity during immobility generates structured population patterns that are necessary for forming spatial memories.

The paper investigates how hippocampal neurons perform pattern separation using multiple coding strategies and identifies the role of inhibitory signals in this process.

The paper demonstrates temporal pattern separation in hippocampal neurons by showing that output spiketrains of DG granule cells are more dissimilar than their inputs.