Jill K. Leutgeb

Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

This study investigates how the medial entorhinal cortex (mEC) maintains information during working memory, finding that low-dimensional neural dynamics, not limited to grid cells, support memory retention through recurring activity patterns.

NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons

This study shows that NPAS4 deletion in CA1 pyramidal neurons impairs spatial representation and temporal precision of spiking.

Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy.

This study shows that early in temporal lobe epilepsy, the dentate gyrus has impaired pattern separation despite stable spatial coding, linking network changes to memory deficits.

Mental exploration of future choices during immobility theta oscillations

The paper shows that theta oscillations during immobility in the hippocampus support mental exploration of future choices by encoding remote locations, particularly next choices in a working memory task.

Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells

Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience

The paper shows that low-rate hippocampal activity during brief intervals encodes sensory-motor experience in rodents, present in both working and non-working memory tasks.

Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns

This study shows that localized APP pathology in hippocampal CA3 cells leads to altered neuronal firing patterns in connected regions, suggesting disease progression can occur through physiological dysfunction rather than just spreading pathology.

Directional Tuning of Phase Precession Properties in the Hippocampus

The paper investigates the relationship between directional rate codes and theta sequence directionality in hippocampal place cells, finding that rate and spike timing codes are related with distinct effects in different subregions.

Theta oscillations in the prefrontal-hippocampal circuit do not couple to respiration-related oscillations

The paper investigates whether theta oscillations in the prefrontal-hippocampal circuit couple with respiration-related oscillations during odor-cued working memory tasks and finds they do not.