Stefan Leutgeb

This study investigates how the medial entorhinal cortex (mEC) maintains information during working memory, finding that low-dimensional neural dynamics, not limited to grid cells, support memory retention through recurring activity patterns.

This study shows that NPAS4 deletion in CA1 pyramidal neurons impairs spatial representation and temporal precision of spiking.

This study shows that early in temporal lobe epilepsy, the dentate gyrus has impaired pattern separation despite stable spatial coding, linking network changes to memory deficits.

The paper shows that theta oscillations during immobility in the hippocampus support mental exploration of future choices by encoding remote locations, particularly next choices in a working memory task.

The paper shows that low-rate hippocampal activity during brief intervals encodes sensory-motor experience in rodents, present in both working and non-working memory tasks.

This study shows that localized APP pathology in hippocampal CA3 cells leads to altered neuronal firing patterns in connected regions, suggesting disease progression can occur through physiological dysfunction rather than just spreading pathology.

The paper investigates whether theta oscillations in the prefrontal-hippocampal circuit couple with respiration-related oscillations during odor-cued working memory tasks and finds they do not.

This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.