Systems BiologybioRxivPreprint
EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA
Avery M. Runnebohm, H. R. Sagara Wijeratne, Monica P. Barron…·Amber L. Mosley
The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.
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