H. R. Sagara Wijeratne

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

This study uses a Drosophila model to show that RNA exosome mutations disrupt brain transcriptomes and cause neurodegeneration by altering rRNA processing.

This study compares two charge-change correction strategies for {lambda}-dynamics free energy calculations, finding that a simplified AC approach is more generalizable than CI for protein mutations.

The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.

The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

This study shows RPLP1 and RPLP2 enhance ribosome elongation and protein stability for flaviviral and cellular multi-pass transmembrane proteins by relieving ribosome pausing.

This study investigates the role of Piwil1 in mouse neocorticogenesis, finding it essential for cell cycle, neuron migration, and dendritogenesis, with effects independent of piRNA expression.