Amber L. Mosley

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

This study identifies CaMKK2 as a dual-function regulator of chondrocyte proteostasis by scaffolding the UPS-Ubr4-19S proteasome complex and enhancing proteasome activity through Psmc5 phosphorylation.

This study identifies changes in non-histone lysine methylation during neuronal differentiation of LUHMES cells using quantitative proteomics.

This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.

This study shows that PP2A activation inhibits macropinocytosis and induces cell death in pancreatic ductal adenocarcinoma, suggesting PP2A activators could be used with metabolic inhibitors as a new therapeutic strategy.

This study compares two charge-change correction strategies for {lambda}-dynamics free energy calculations, finding that a simplified AC approach is more generalizable than CI for protein mutations.

This paper identifies VDAC1 as the target of SW016789, a hypersecretion inducer, and shows it causes distinct transcriptomic changes in beta-cells compared to ER stress.

The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.

The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.

The paper uses ID-oPD to map spinophilin's interactome, identifying proteins involved in mRNA processing and translation, and suggests a role in synaptic protein expression.

The paper quantifies non-histone lysine methylation sites and lysine demethylases in breast cancer cell lines using TMT labeling without antibody enrichment, identifying differentially abundant sites and enzymes.

The paper compares BioID variants in budding yeast, identifies TurboID as the most effective, and explores the Ccr4-Not complex interactome.

The paper identifies how the Paf1 complex subunit Rtf1 interacts with Rad6 to stimulate H2B ubiquitylation, revealing a conserved interface that guides substrate specificity during transcription.

This study investigates how prenatal methadone exposure affects protein and phosphoprotein levels in specific brain regions of mice, showing unique changes in the primary motor cortex linked to synaptic function.

The paper investigates the role of spinophilin in mediating mGluR5-dependent repetitive motor dysfunction in striatal neurons, showing subtype-specific effects on grooming behavior and synaptic plasticity.

The paper optimizes the analysis workflow for Thermal Proteome Profiling data to improve the accuracy of protein stabilization/destabilization identification and provides an R-based tool for community use.

This study defines the Hrq1 interactome in yeast using multi-omics approaches, revealing its role in DNA repair, transcription, and ICL repair, and linking it to human RECQL4 disease mechanisms.

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

This paper shows that Rtr1 prevents premature transcription termination by restricting the NNS-dependent termination pathway and facilitating low-level elongation of noncoding transcripts.