Lauryn A. Cureton

EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA

The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.

Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation

The paper compares disease-linked missense mutations in the RNA exosome using yeast models to identify shared and distinct functional consequences in translation.

A Biallelic Variant of the RNA Exosome Gene EXOSC4 Causes Translational Defects Associated with a Neurodevelopmental Disorder

This paper identifies a biallelic EXOSC4 variant causing translational defects and a neurodevelopmental disorder through functional studies in yeast.