Zong Ming Chua

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotype

This study shows that a H2A.Z mutant reduces the senescence-associated secretory phenotype in human fibroblasts without affecting cell cycle genes.

HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

Nucleosome stability safeguards cell identity, stress resilience and healthy aging

The paper shows that reduced nucleosome stability impairs cell identity, stress resilience, and healthy aging across species.

PROTGOAT : Improved automated protein function predictions using Protein Language Models

PROTGOAT improves protein function prediction using an ensemble of pre-trained protein language models, achieving high performance in CAFA 5 benchmark.

Transcriptome-wide profiles of circular RNA and RNA binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

The paper identifies circRNA-RBP interactions in cancer, showing their role in circRNA biogenesis and cancer gene expression, with implications for bladder cancer prognosis.