Isoform-Specific Control of Adipose Thermogenesis by the miR-27 Family Reveals Antagonism within a Polycistronic miRNA Cluster
Devesh Kesharwani, Michele J. Karolak, Chad C. Doucette, Eric R. Loomis, Sophia E Adami-Sampson, Su Su, Victoria DeMambro, Clifford james Rosen, Anne Harington, Larisa Ryzhova, Lucy Liaw, Aaron Clifford Brown
This study shows that miR-27a and miR-27b regulate adipose thermogenesis and metabolism, with their combined loss enhancing thermogenic activity and metabolic health.
bioRxiv · Jul 21, 2025 · PreprintPhysiology