Clifford james Rosen

This study identifies exosome trafficking as a key regulator of beige adipocyte thermogenesis, showing that exosome release enhances thermogenic output and energy expenditure.

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

This study shows that miR-27a and miR-27b regulate adipose thermogenesis and metabolism, with their combined loss enhancing thermogenic activity and metabolic health.

The paper examines transcriptional changes in adipose tissue from subacute COVID-19 and Long COVID patients, finding no persistent viral RNA but significant transcriptional remodeling in subacute cases and no consistent gene expression differences in Long COVID.

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

This study shows that reducing Fshr expression in Alzheimer's mice improves spatial memory, with gene-dose-dependent effects, and links low FSH levels to better memory retrieval.

The paper identifies shared molecular mechanisms between Alzheimer's Disease and Osteoporosis using transcriptomic network analysis across brain and bone tissues.

The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

The paper creates a comprehensive neuroanatomical atlas of glycoprotein hormone receptor expression in the brain using single-transcript detection technologies.

This study shows Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells toward adipogenesis through C3 and Wnt/β-catenin signaling inhibition.

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.