Enzymatic attachment of antigens to probe immune modulation by skin commensals
Djenet Bousbaine, Pranav V. Lalgudi, Katherine D. Bauman, Eunice Tsang, Tam T.D. Nguyen, Anchaleena James, Miki Chiang, Aishan Zhao, Masahiko Terasaki, Joyce M. Swenson, Anne Trinh, Michael A. Fischbach
This study uses recombinant sortase to attach antigens to Gram-positive bacteria, demonstrating a non-genetic method to induce protective immunity in vivo.
bioRxiv · Nov 3, 2026 · PreprintImmunology