Microbial mechanistic requirements for eliciting a topical and intranasal immune response
Katherine D. Bauman, Pranav V. Lalgudi, Djenet Bousbaine, Anchaleena James, Miki L. Chiang, Tam T. D. Nguyen, Joyce M. Swenson, Eunice Tsang, H J Kim, Felicitas Ruiz, Naveen Jasti, Zachary Jones, David B. Li, Annie T Nguyen, Anne Trinh, , Michael Andrew Fischbach
This study demonstrates that Staphylococcus epidermidis can be engineered to elicit potent immune responses when applied topically or intranasally, with nasal colonization inducing stronger systemic and mucosal immunity.
bioRxiv · Jul 16, 2026 · PreprintMicrobiology