Michael Andrew Fischbach

This study uses recombinant sortase to attach antigens to Gram-positive bacteria, demonstrating a non-genetic method to induce protective immunity in vivo.

Minerva extracts RNA base-pairing, protein-contact and repeat maps from a genome language model without alignments, flagging unannotated structured loci and a phage ncRNA array reverse-transcribed into short cDNAs.

The paper shows that T cells specific for microbiota and diet antigens predominantly become regulatory T cells (iTregs) in the gut, with effector responses emerging only under specific inflammatory and genetic conditions.

This study shows that gut microbial composition affects food allergen-specific CD4+ T cells, leading to differences in food allergy severity between mouse strains.

This study demonstrates that Staphylococcus epidermidis can be engineered to elicit potent immune responses when applied topically or intranasally, with nasal colonization inducing stronger systemic and mucosal immunity.

The paper shows that modifying microbial community composition, specifically overexpressing bile acid metabolic genes in Lactobacillus strains, can alter bile acid pool size and composition in mice.

The paper uses a single-strain dropout screen in a defined microbial community to show how removing specific strains affects community composition and metabolic output.

The paper identifies seed storage protein epitopes as targets of intestinal regulatory T cells that modulate immune responses to dietary antigens.

This study shows that gut microbe-derived short-chain fatty acids reduce joint inflammation after alphavirus infection by modulating immune cell activity.

This study identifies regulators of AHR signaling in hepatocytes using CRISPR screening, revealing novel mechanisms and cell-type-specific components for therapeutic targeting.

This study analyzes the gut microbiome of humpback whales during feeding and fasting periods, revealing significant taxonomic and functional changes associated with migration and fasting.

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.

BiG-MAP profiles metabolic gene cluster abundance and expression in microbiomes, identifying clusters associated with oral health and disease.

This study systematically profiles primary metabolic genes in the human gut microbiota, revealing pathway differences among phyla and showing limited correlation between gene abundance and metabolite levels in plasma.

The paper identifies diverse gene clusters containing Fe-S flavoenzymes in gut microbiota, suggesting their broad role in metabolic pathways and potential impact on human health.