Minimally invasive myocardial infarction model recapitulates patient immune responses and reveals a pathogenic role for immature neutrophils
Zoe Möller-Ramon, Anna Cristina Kaltenbach, Sarah‐Lena Puhl, Immanuel Kwok, Florian Sicklinger, Yvonne J. F. M. Jansen, Annick Ernst, Katrin Nitz, Maximilian J. Schloss, Florian Leuschner, Mark Yan Yee Chan, Christian Weber, Sabine Steffens, Johan Duchêne
This study compares two myocardial infarction models, showing the intact-chest model better reflects human immune responses and identifies immature neutrophils as contributors to cardiac dysfunction.
bioRxiv · Mar 11, 2026 · PreprintImmunology