GeneticsbioRxivPreprint
CRISPRa-induced upregulation of human LAMA1 compensates for LAMA2-deficiency in Merosin-deficient congenital muscular dystrophy
Annie I. Arockiaraj, Marie A. Johnson, Anushe Munir…·Dwi U. Kemaladewi
This study shows that CRISPRa-mediated upregulation of LAMA1 compensates for LAMA2 deficiency in MDC1A fibroblasts, reducing cell migration and related pathway activity.
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