Author

Linda M. McAllister‐Lucas

University of PittsburghORCID 0000-0002-9875-5043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Peter C. LucasiD· 2 shared Prasanna EkambaramiD· 2 shared Riyue BaoiD· 2 shared A. Carolina TufinoiD· 1 shared Adam C. OlsoniD· 1 shared Aivi T. NguyeniD· 1 shared Andrew P. HinckiD· 1 shared Annie I. Arockiaraj· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Peter C. LucasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression

J. Hofstatter Azambuja, Saigopalakrishna S. Yerneni, Lisa M. Maurer, Hannah E. Crentsil, Gabriela Nogueira Debom, Linda R. Klei, Mei Smyers, Chaim T. Sneiderman, Kristina Elsa Schwab, Rajesh Acharya, Aivi T. Nguyen, Josie L. Emery, John W. Little, Jeffrey A. Meridew, Yijen Lin Wu, , Linda M. McAllister‐Lucas

This study shows that inhibiting MALT1 protease in glioblastoma-associated macrophages reduces immunosuppression and tumor growth by reprogramming macrophages to an M1-like phenotype.

Nature Communications · Aug 10, 2026Peer-reviewedCancer Biology

Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation

Jessica D. Daley, Elina Mukherjee, A. Carolina Tufino, Nathanael G. Bailey, Shanthi Bhaskar, Nivitha Periyapatna, Ian MacFawn, Sheryl R. Kunning, Cynthia S. Hinck, Tullia Carmela Bruno, Adam C. Olson, Linda M. McAllister‐Lucas, Andrew P. Hinck, Kristine L. Cooper, Riyue Bao, , Kelly M. Bailey

The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.

bioRxiv · May 7, 2024 · PreprintCancer Biology

CRISPRa-induced upregulation of human LAMA1 compensates for LAMA2-deficiency in Merosin-deficient congenital muscular dystrophy

Annie I. Arockiaraj, Marie A. Johnson, Anushe Munir, Prasanna Ekambaram, Peter C. Lucas, Linda M. McAllister‐Lucas, Dwi U. Kemaladewi

This study shows that CRISPRa-mediated upregulation of LAMA1 compensates for LAMA2 deficiency in MDC1A fibroblasts, reducing cell migration and related pathway activity.

bioRxiv · Mar 6, 2023 · PreprintGenetics