Functional analysis of a common BAG3 allele associated with protection from heart failure
Juan A. Pérez-Bermejo, Luke M. Judge, Christina L Jensen, Kenneth Kun-yu Wu, Hannah L. Watry, Annie Truong, Jaclyn J. Ho, Matthew Carter, Wendy V. Runyon, Robyn M. Kaake, Ernst H. Pulido, Mohammad A. Mandegar, Danielle L. Swaney, Po-Lin So, Nevan J. Krogan, Bruce R. Conklin
This study investigates the functional impact of a BAG3 allele associated with reduced heart failure risk, showing it enhances cardiomyocyte stress resistance through altered protein interactions.
Nature Cardiovascular Research · Jun 26, 2023Peer-reviewedGenetics