Mohammad A. Mandegar

This study identifies epigenetic and cell cycle regulators that enhance AAV production by analyzing transcriptomic responses in cell lines with varying production capacities.

This study investigates the functional impact of a BAG3 allele associated with reduced heart failure risk, showing it enhances cardiomyocyte stress resistance through altered protein interactions.

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.