Robyn M. Kaake

Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells

This study shows that SARS-CoV-2's ORF8 protein reprograms macrophages to enhance viral infection of lung epithelial cells, contributing to lung pathology in COVID-19.

Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways

This study shows HIV-1 infected immune cells alter cervical cancer pathways through paracrine signals, with upregulated PI3K-AKT and interferon-stimulated genes.

LANA-dependent Interaction of Host Factors DAXX and BRD4 Impact KSHV Lytic Replication

This paper identifies DAXX and BRD4 as LANA-interacting host factors that support KSHV latency, while LIG3 is required for lytic reactivation, revealing their roles in viral replication.

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion

This study identifies SLC2A3 as a key factor for Old World alphavirus neuroinvasion through BBB infection, revealing a conserved mechanism across multiple viruses.

Functional analysis of a common BAG3 allele associated with protection from heart failure

This study investigates the functional impact of a BAG3 allele associated with reduced heart failure risk, showing it enhances cardiomyocyte stress resistance through altered protein interactions.

Biophysical basis of cellular multi-specificity encoded in a model molecular switch

The paper investigates how the GTPase Ran/Gsp1 achieves functional multi-specificity through biophysical and genetic perturbations, revealing that its effects are linked to kinetic parameters of the switch cycle rather than direct interaction sites.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.